A lot of my ideas about Machine Learning come from Quantum Mechanical Perturbation Theory. To provide some context, we need to step back and understand that the familiar techniques of Machine Lear…
Category Archives: Computational Genomics
Fancy a challenge? A DREAM of intra-tumour phylogenies
a big chance for dry labs
You are into tumor evolution? And got a fancy model? Want to battle with the best?
Then check out the ICGC-TCGA DREAM Somatic Mutation Calling – Tumour Heterogeneity Challenge (SMC-Het).
These are the days of Big Science, my friend. You can’t just have a short name …
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Inferring tumour evolution 2 – Comparison to classical phylogenetics
Quick recap: Last time we talked about tumor evolution and I presented a toy example to introduce key concepts. I also introduced the intra-tumor phylogeny problem: Given a sample of the genomes of clones in a tumour, reconstruct its `life history’. This problem consists of two sub-problems: (1)identification of clones, and (2) inferring evolutionary relationships between clones.
This problem falls into the general area of reconstructing phylogenetic trees — so how does inferring clonal trees compare to classical phylogenetic methods?
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计算基因组学研究组 