Category Archives: Computational Genomics

Social network, machine learning and disease-genes

Some recent paper on how disease gene network works and the metastasis of cancer. Machine  Learning is a good tool for study the relation between individual gene and disease.  here are the papers:

Infectious Disease Modeling of Social Contagion in Networks

Alison L. Hill1,2*, David G. Rand1,3, Martin A. Nowak1,4,5,Nicholas A. Christakis6,7,8

Information, trends, behaviors and even health states may spread between contacts in a social network, similar to disease transmission. However, a major difference is that as well as being spread infectiously, it is possible to acquire this state spontaneously. For example, you can gain knowledge of a particular piece of information either by being told about it, or by discovering it yourself. In this paper we introduce a mathematical modeling framework that allows us to compare the dynamics of these social contagions to traditional infectious diseases. We can also extract and compare the rates of spontaneous versus contagious acquisition of a behavior from longitudinal data and can use this to predict the implications for future prevalence and control strategies. As an example, we study the spread of obesity, and find that the current rate of becoming obese is about 2 per year and increases by 0.5 percentage points for each obese social contact, while the rate of recovering from obesity is 4per year. The rates of spontaneous infection and transmission have steadily increased over time since 1970, driving the increase in obesity prevalence. Our model thus provides a quantitative way to analyze the strength and implications of social contagions.

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A Free Online Book on Human Genome

Recently, I just read a online book on Human Genome. Its an well write book, thanks the author for share. Enjoy the Book:

Human Molecular Genetics, 2nd edition

Tom Strachan1 and Andrew P Read2
1University of Newcastle, Newcastle-upon-Tyne, UK
2University of Manchester, Manchester, UK
New York: Wiley-Liss; 1999.
ISBN: 1-85996-202-5
Excerpt

The idea for this book grew from two earlier efforts, The Human Genome (TS; BIOS Scientific Publishers, 1992) and Medical Genetics, an Illustrated Outline (APR; Gower Medical Publishing, 1989). In these small books we tried to develop a treatment of human genetics based on understanding the structure and function of the normal human genome. Traditionally, textbooks of human genetics tended to start by considering meiosis and the way diseases segregate in pedigrees, whilst textbooks of molecular genetics rarely emphasized human topics. Until recently this was inevitable because so little was understood about the normal human genome. The Human Genome Project has changed all that, and the present book is an attempt to provide a comprehensive integrated study of human molecular genetics.

Table of Contents

SVMs in computational Biology

Support vector machines (SVMs) are a set of supervised learning methods, they could used in statistical patterns classification and recognize.  As its easy extension and  could be deal the high dimension data, its could be used widely in computational biology. Here are two paper published in Education issue of  Plos Computational, which introduced Machine Learning and SVMs to Computational Biology:

1. Support Vector Machines and Kernels for Computational Biology

Asa Ben-Hur1#, Cheng Soon Ong2,3#¤, Sören Sonnenburg4, Bernhard Schölkopf3, Gunnar Rätsch2*

1 Department of Computer Science, Colorado State University, Fort Collins, Colorado, United States of America, 2 Friedrich Miescher Laboratory, Max Planck Society, Tübingen, Germany, 3 Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 4 Fraunhofer Institute FIRST, Berlin, Germany

Introduction

The increasing wealth of biological data coming from a large variety of platforms and the continued development of new high-throughput methods for probing biological systems require increasingly more sophisticated computational approaches. Putting all these data in simple-to-use databases is a first step; but realizing the full potential of the data requires algorithms that automatically extract regularities from the data, which can then lead to biological insight.

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Personal genomes

Advances in genome science and technology offer a deeper understanding of biology while at the same time improving the practice of medicine. Genomics information could tell  us more story on our health.In 2008, Nature offered a special focus on “Personal Genomics” to focus on the on how genomes information help us known our health. As the price of sequencing is deducing, someday can say that my gene, my health. Here is a snapshot from Nature.

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